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Anadrol History and Overview: Anadrol is known (sometimes notoriously) as being one of the contenders for being the strongest oral anabolic steroid commercially available. It comes in multiple sizes ranging from an ad libitum dose of approximately 10-20 mg which is used off labels as a muscle builder and for improving body composition and recovery. It is usually administered to patients at a dose of 3-10 mg or as needed. Anadrol is considered an anabolic steroid based on its actions on IGF-1, the protein that stimulates the growth of muscle tissue. It is also known by the trade name DHLA (delta-hydroxy-lutaryl-glutamic acid), a derivative of nandrolone, and the synthetic name of nandrolone, a combination of the two. Anandamide is a neurotransmitter that affects many aspects of nerve function, including the release and/or reuptake of growth hormone and IGF-1. Anandamide has been reported to increase androgen receptors (AR) in the hypothalamus, thereby increasing the expression of androgen receptors. Anandamide has also been found to block the action of androgen on ARs and therefore increase the rate of muscle fiber growth. Thus, it has been demonstrated that anabolic steroids increase muscle size independently of androgen receptors, but that anandamide increases AR functions. Anandamide and GH, also known as GH-releasing hormone, have been shown to have a synergistic effect with each other on the release of growth hormone and IGF-1 in muscle tissue. Anandamide blocks the action of IGF-1 on ARs, hence increasing the rate of muscle fiber growth. Although these effects are reported to occur at very low dosages (often 1 mg/kg), clinical studies demonstrate a wide variety of anabolic effects of anandamide in animals. The effect of anandamide on GH release in the absence of androgen receptors is also reported to be similar to that of IGF-1, thus the increased the rate of muscle growth. The effects of anandamide have also been shown to be mediated through an AR mediated effect on the release of insulin. The activation of the prolactin gene in mice has been associated with increased GH release and IGF-1 release. These effects of anandamide on muscle protein synthesis in cultured muscle have also been studied in various laboratory animal models via a variety of approaches, including microdialysis, intracerebral infusion, intracavernostatic infusion, and in vivo experiments. Anandamide has been found to increase muscle protein synthesis by increasing myogenin mRNA transcription at a time after its stimulation, possibly by Related Article: